The effect of estrogen and progesterone on spreading depression in rat neocortical tissues

@article{Sachs2007TheEO,
  title={The effect of estrogen and progesterone on spreading depression in rat neocortical tissues},
  author={M Sachs and Hans-Christian Pape and Erwin Josef Speckmann and Ali Gorji},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={27-34}
}
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49 Citations
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49 Citations

Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex

TLDR
Results indicate that D2 receptors modulate the initiation of SD in the neocortex, and refers to the potential role of D2 receptor antagonist in treatment of migraine pain.

Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura

TLDR
5-HTP decreases CSD occurrence in the presence of ovarian hormones, suggesting its potential efficacy in migraine with aura prophylaxis in females and may explain why migraine auras can appear during pregnancy and why menstrual-related migraine attacks are rarely associated with an aura.

Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat

Alterations in the threshold of the potassium concentration to evoke cortical spreading depression during the natural estrous cycle in mice

Patterns of neurotransmitter receptor distributions following cortical spreading depression

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

TLDR
This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies.

Effects of garlic extract on spreading depression: In vitro and in vivo investigations

TLDR
Garlic oil suppresses CSD, likely via inhibition of synaptic plasticity, and prevents its harmful effects on astrocyte, and may have the potential to use in treatment of CSD-related disorders.

Effect of Cannabinoid Receptor Activation on Spreading Depression

TLDR
Suppression of CSD by activation of CB1 receptors points to the potential therapeutic effects of cannabinoids in migraine with aura.

Reply

TLDR
A dose-dependent enhancement of the neocortical susceptibility to CSD occurrence in the presence of ovarian hormones is indicated, indicating both neuronal and synaptic facilitation induced by these hormones may reduce the CSD threshold and may be responsible for increased migraine attacks in women.

The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer’s Disease

TLDR
The molecular mechanism of potential estradiol modulatory action on endogenous neurogenesis, synaptic plasticity, and cognitive function in AD is discussed and may provide preventive and/or therapeutic approaches for AD.

References

SHOWING 1-10 OF 74 REFERENCES

Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues

Limbic system involvement in the increase in plasma prolactin following cortical spreading depression in gonadotropin-treated female rats.

TLDR
The results indicate that limbic structures play a significant role in the mechanisms by which cortical SD elevates plasma prolactin levels under the present experimental conditions.

Plasma LH changes following cortical spreading depression in female rats.

The effects of KCl-induced cortical spreading depression on plasma LH levels were studied by radioimmunoassay in ovariectomized (OVX), ovariectomized, estrogen-progesteroneprimed (OEP) and intact…

Effects of Spreading Depression on Stress-Induced Changes in Plasma Prolactin and LH 1

  • J. ColomboC. Sawyer
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1975
TLDR
Female rats rendered “pseudo-pregnant” by treatment with PMS and hCG and ovariectomized rats injected with estradiol and progesterone were subjected to cortical spreading depression, indicating that cortical SD suppresses the stress responses observed in saline-treated control animals.

Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat

Steroid Hormones and Excitability in the Mammalian Brain

  • M. Joëls
  • Biology, Medicine
    Frontiers in Neuroendocrinology
  • 1997
TLDR
The diverse actions of steroid hormones on single cell activity have consequences for the excitability in local circuits in which these cells participate, and this is illustrated in this review for two processes that depend on circuit rather than single cell function.

Effects of clomethiazole on spreading depression in the rat hippocampal slice.

  • T. Stone
  • Biology
    European journal of pharmacology
  • 2000

Hormone-Related Headache

TLDR
The prevalence of migraine decreases with advancing age and it improves in many, but not all, women after the menopause, however, in the perimenopausal period, migraine may worsen as a result of fluctuations in estrogen levels.

Neurosteroid modulation of GABAA receptors

Abnormal luteal phase excitability of the motor cortex in women with premenstrual syndrome

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