The effect of estrogen and progesterone on spreading depression in rat neocortical tissues

@article{Sachs2007TheEO,
  title={The effect of estrogen and progesterone on spreading depression in rat neocortical tissues},
  author={M Sachs and Hans-Christian Pape and Erwin Josef Speckmann and Ali Gorji},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={27-34}
}
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49 Citations
Highly Influential Citations
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49 Citations

Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
TLDR
Results indicate that D2 receptors modulate the initiation of SD in the neocortex, and refers to the potential role of D2 receptor antagonist in treatment of migraine pain.
Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura
TLDR
5-HTP decreases CSD occurrence in the presence of ovarian hormones, suggesting its potential efficacy in migraine with aura prophylaxis in females and may explain why migraine auras can appear during pregnancy and why menstrual-related migraine attacks are rarely associated with an aura.
Influence of Ovarian Hormones on Cortical Spreading Depression and Its Suppression by L-kynurenine in Rat
TLDR
The results show that both estradiol and progesterone increase CSD frequency after ovariectomy, which may explain why clinically migraine with aura appears or worsens during pregnancy or with combined hormonal treatments.
Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat
Alterations in the threshold of the potassium concentration to evoke cortical spreading depression during the natural estrous cycle in mice
Patterns of neurotransmitter receptor distributions following cortical spreading depression
17-β-Estradiol induces spreading depression and pain behavior in alert female rats
TLDR
This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies.
Reply
TLDR
A dose-dependent enhancement of the neocortical susceptibility to CSD occurrence in the presence of ovarian hormones is indicated, indicating both neuronal and synaptic facilitation induced by these hormones may reduce the CSD threshold and may be responsible for increased migraine attacks in women.
Cortical spreading depression modulates synaptic transmission of the rat lateral amygdala
TLDR
The results indicate the disturbances of LA synaptic transmission triggered by propagation of CSD may relate to some symptoms occurring during migraine attacks.
The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer’s Disease
TLDR
The molecular mechanism of potential estradiol modulatory action on endogenous neurogenesis, synaptic plasticity, and cognitive function in AD is discussed and may provide preventive and/or therapeutic approaches for AD.
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References

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Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues
Limbic system involvement in the increase in plasma prolactin following cortical spreading depression in gonadotropin-treated female rats.
TLDR
The results indicate that limbic structures play a significant role in the mechanisms by which cortical SD elevates plasma prolactin levels under the present experimental conditions.
The role of estradiol withdrawal in the etiology of menstrual migraine
TLDR
The aim of the current investigation was to study the role of estradiol in menstrual migraine, and it was concluded that progesterone treatment during the premenstrual phase had little protective effect and that progestogen withdrawal did not precipitate migraine.
Effects of Spreading Depression on Stress-Induced Changes in Plasma Prolactin and LH 1
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TLDR
Female rats rendered “pseudo-pregnant” by treatment with PMS and hCG and ovariectomized rats injected with estradiol and progesterone were subjected to cortical spreading depression, indicating that cortical SD suppresses the stress responses observed in saline-treated control animals.
Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat
Effects of clomethiazole on spreading depression in the rat hippocampal slice.
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Hormone-Related Headache
TLDR
The prevalence of migraine decreases with advancing age and it improves in many, but not all, women after the menopause, however, in the perimenopausal period, migraine may worsen as a result of fluctuations in estrogen levels.
Neurosteroid modulation of GABAA receptors
Abnormal luteal phase excitability of the motor cortex in women with premenstrual syndrome
The pathophysiology of migraine: year 2005
TLDR
It is possible that visual, motor or sensory aura might be responsible for the generation of the pain through the above mechanisms of cortical spreading depression underlies migraine.
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