The effect of estrogen and progesterone on spreading depression in rat neocortical tissues

@article{Sachs2007TheEO,
  title={The effect of estrogen and progesterone on spreading depression in rat neocortical tissues},
  author={M Sachs and Hans-Christian Pape and Erwin Josef Speckmann and Ali Gorji},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={27-34}
}

Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex

TLDR
Results indicate that D2 receptors modulate the initiation of SD in the neocortex, and refers to the potential role of D2 receptor antagonist in treatment of migraine pain.

Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura

TLDR
5-HTP decreases CSD occurrence in the presence of ovarian hormones, suggesting its potential efficacy in migraine with aura prophylaxis in females and may explain why migraine auras can appear during pregnancy and why menstrual-related migraine attacks are rarely associated with an aura.

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

TLDR
This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies.

Effects of garlic extract on spreading depression: In vitro and in vivo investigations

TLDR
Garlic oil suppresses CSD, likely via inhibition of synaptic plasticity, and prevents its harmful effects on astrocyte, and may have the potential to use in treatment of CSD-related disorders.

Effect of Cannabinoid Receptor Activation on Spreading Depression

TLDR
Suppression of CSD by activation of CB1 receptors points to the potential therapeutic effects of cannabinoids in migraine with aura.

Reply

TLDR
A dose-dependent enhancement of the neocortical susceptibility to CSD occurrence in the presence of ovarian hormones is indicated, indicating both neuronal and synaptic facilitation induced by these hormones may reduce the CSD threshold and may be responsible for increased migraine attacks in women.

The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer’s Disease

TLDR
The molecular mechanism of potential estradiol modulatory action on endogenous neurogenesis, synaptic plasticity, and cognitive function in AD is discussed and may provide preventive and/or therapeutic approaches for AD.

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TLDR
The results indicate that limbic structures play a significant role in the mechanisms by which cortical SD elevates plasma prolactin levels under the present experimental conditions.

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The effects of KCl-induced cortical spreading depression on plasma LH levels were studied by radioimmunoassay in ovariectomized (OVX), ovariectomized, estrogen-progesteroneprimed (OEP) and intact

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TLDR
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TLDR
The prevalence of migraine decreases with advancing age and it improves in many, but not all, women after the menopause, however, in the perimenopausal period, migraine may worsen as a result of fluctuations in estrogen levels.
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