The effect of epidermal growth factor on membrane potential. Rapid hyperpolarization followed by persistent fluctuations.

@article{Pandiella1989TheEO,
  title={The effect of epidermal growth factor on membrane potential. Rapid hyperpolarization followed by persistent fluctuations.},
  author={Atanasio Pandiella and Michele Magni and Davide Lovisolo and Jacopo Meldolesi},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 22},
  pages={
          12914-21
        }
}
The effects of epidermal growth factor (EGF) on membrane potential were investigated in suspensions of the following three cell types endowed with a large complement of specific receptors: EGFR-T17 (a clone of mouse NIH-3T3 fibroblasts overexpressing EGF receptors); A431 and KB (two human carcinoma lines). In all these lines EGF induced a rapid and marked hyperpolarization constituted by an initial peak (in all three cell lines) and a subsequent sustained plateau phase, concomitant with the… CONTINUE READING

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