The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones.

@article{Chang2000TheEO,
  title={The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones.},
  author={S L Chang and G{\"u}nter A Hofmann and Liqiang Zhang and Leonard John Deftos and Ajay K. Banga},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2000},
  volume={66 2-3},
  pages={127-33}
}
Electrically-assisted delivery by iontophoresis and/or electroporation was used in vitro to deliver the calcium regulating hormones, salmon calcitonin (sCT) and parathyroid hormone (1-34) (PTH) through human epidermis. Such delivery could be useful for chronic treatment of post-menopausal osteoporosis and other clinical indications as a superior alternative to parenteral delivery. sCT (50 microg/ml) or PTH (1-34) (100 microg/ml) formulation was prepared in citrate buffer (pH 4.0 or 5.0… CONTINUE READING

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