The effect of dutasteride on the usefulness of prostate specific antigen for the diagnosis of high grade and clinically relevant prostate cancer in men with a previous negative biopsy: results from the REDUCE study.

@article{Andriole2011TheEO,
  title={The effect of dutasteride on the usefulness of prostate specific antigen for the diagnosis of high grade and clinically relevant prostate cancer in men with a previous negative biopsy: results from the REDUCE study.},
  author={Gerald L. Andriole and David G. Bostwick and Otis W Brawley and Leonard G. Gomella and Michael J Marberger and Francesco Montorsi and Curtis A. Pettaway and Teuvo L. J. Tammela and Cl{\'a}udio Teloken and Donald J. Tindall and Stephen J. Freedland and Matthew C Somerville and Timothy H. Wilson and Ivy L Fowler and Ramiro S Castro and Roger S Rittmaster},
  journal={The Journal of urology},
  year={2011},
  volume={185 1},
  pages={126-31}
}
PURPOSE We assessed whether dutasteride enhances the usefulness of total prostate specific antigen for diagnosing clinically significant prostate cancer. MATERIALS AND METHODS The 4-year REDUCE study evaluated the efficacy and safety of 0.5 mg dutasteride daily for prostate cancer risk reduction in men with a prostate specific antigen of 2.5 to 10.0 ng/ml and a negative prostate biopsy. Specificity, sensitivity, and positive and negative predictive values of prostate specific antigen for the… CONTINUE READING

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Prediction of prostate cancer for patients receiving finasteride: results from the Prostate Cancer Prevention Trial

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