The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.

@article{Kindel2010TheEO,
  title={The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.},
  author={Tammy Lyn Kindel and Stephanie M. Yoder and David A D'Alessio and Patrick Tso},
  journal={Obesity surgery},
  year={2010},
  volume={20 6},
  pages={768-75}
}
BACKGROUND Enteroendocrine K cells secrete the incretin hormone glucose-dependent insulinotropic peptide (GIP) and are predominately located in the duodenum. GIP levels should decrease after gastric bypass due to duodenal exclusion; however, studies have found conflicting data regarding the changes in GIP secretion after gastric bypass and duodenal-jejunal bypass (DJB). METHODS We performed a DJB or Sham surgery on Wistar rats followed by an oral glucose tolerance test on postoperative (post… CONTINUE READING