The effect of dual ligand-targeted micelles on the delivery and efficacy of poorly soluble drug for cancer therapy.

@article{Sawant2013TheEO,
  title={The effect of dual ligand-targeted micelles on the delivery and efficacy of poorly soluble drug for cancer therapy.},
  author={Rupa R. Sawant and Aditi M. Jhaveri and Alexander Koshkaryev and Farooq Z Qureshi and Vladimir Torchilin},
  journal={Journal of drug targeting},
  year={2013},
  volume={21 7},
  pages={630-8}
}
We prepared and evaluated transferrin (Tf) and monoclonal antibody (mAb) 2C5-modified dual ligand-targeted poly(ethylene glycol)-phosphatidylethanolamine micelles loaded with a poorly soluble drug, R547 (a selective adenosine triphosphate-competitive cyclin-dependent kinase inhibitor) for enhancement of targeting efficiency and cytotoxicity in vitro and in vivo to A2780 ovarian carcinoma compared to single ligand-targeted micelles. Micellar solubilization significantly improved the solubility… CONTINUE READING