The effect of drugs used in anticoagulation therapy on T lymphocyte activation in vitro. II. Warfarin inhibits T lymphocyte activation.

Abstract

The effect of warfarin on T lymphocyte activation in vitro was investigated. Warfarin was found to cause a dose-dependent inhibition of both antigen- and PHA-stimulated proliferation. The drug had to be present during the early steps in T lymphocyte activation to cause inhibition. Warfarin seemed to have no effect on antigen processing or presentation… (More)

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