The effect of drug therapy against a histologically defined rat leukemia.

@article{Pearson1974TheEO,
  title={The effect of drug therapy against a histologically defined rat leukemia.},
  author={John W. Pearson and S. D. Chaparas and J A Torgersen and Kaiman Perk and Michael A. Chirigos and Neal A Sher},
  journal={Cancer research},
  year={1974},
  volume={34 2},
  pages={355-61}
}
A spontaneous rat leukemia, free of oncornaviruses, was defined pathologically and shown to be useful as a model system for testing three clinically active drugs. Histologi cally, the disease is a lymphoblastic leukemia, with virtually all organs densely infiltrated by leukemic cells. Treatment with specific doses of Cytoxan and melphalan resulted in a… CONTINUE READING