The effect of drug dose and drug exposure time on the binding, internalization, and cytotoxicity of radiolabeled somatostatin analogs.

@article{Anthony2004TheEO,
  title={The effect of drug dose and drug exposure time on the binding, internalization, and cytotoxicity of radiolabeled somatostatin analogs.},
  author={Catherine Tananis Anthony and Susan Hughey and J. -A. Lyons and Sean Weiss and Conrad A. Hornick and George J. Drouant and Joseph A. Fuselier and David H. Coy and William A. Murphy and Eugene A. Woltering},
  journal={The Journal of surgical research},
  year={2004},
  volume={119 1},
  pages={
          1-13
        }
}
BACKGROUND Creation of protease-resistant somatostatin analogs has allowed development of these peptides as clinically useful drugs. Widespread diagnostic use of radiolabeled somatostatin analogs has enhanced interest in the binding and intracellular distribution of these peptides. The degree of drug internalization and length of drug retention may be critical for drug-induced cytotoxicity. We hypothesized that the ability of a radiolabeled peptide to bind to a cell, be internalized, and induce… CONTINUE READING