Corpus ID: 25111515

The effect of doxepin on the central action of ethanol.

  title={The effect of doxepin on the central action of ethanol.},
  author={Elżbieta Czarnecka and Bogusława Pietrzak},
  journal={Polish journal of pharmacology and pharmacy},
  volume={43 6},
  • Elżbieta Czarnecka, Bogusława Pietrzak
  • Published 1991
  • Medicine
  • Polish journal of pharmacology and pharmacy
  • The effect of combined treatment with doxepin and ethanol was tested in mice, rats and rabbits. Doxepin was given in a single dose (5 or 10 mg/kg) or chronically (10 mg/kg/d for 21 days). Doxepin did not affect ethanol toxicity and ethanol-induced impairment of rota-rod performance, but potentiated ethanol-induced hypothermia (only acutely) and prolonged ethanol-induced sleep in mice. Given acutely it potentiated the inhibitory effect of ethanol on locomotor activity in mice, while given… CONTINUE READING