The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury.

@article{Ward2003TheEO,
  title={The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury.},
  author={Deborah M Ward and Michael S. Leib and Spencer Johnston and Michele Marini},
  journal={Journal of veterinary internal medicine},
  year={2003},
  volume={17 3},
  pages={282-90}
}
The effect of twice-daily administration of misoprostol on aspirin-induced gastric injury was evaluated. Twenty-four random-source dogs were divided into groups that received aspirin and misoprostol as follows: group I, aspirin 25 mg/kg PO q8h and placebo PO q8h; group II, aspirin 25 mg/kg PO q8h and misoprostol 3 microg/kg PO q8h; group III, aspirin 25 mg/kg PO q8h, misoprostol 3 microg/kg PO q12h, and placebo PO q24h; and group IV, aspirin 25 mg/kg PO q8h, misoprostol 3 microg/kg PO q24h, and… CONTINUE READING
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