The effect of dopamine on the rapidly adapting receptors in the dog lung.

@article{Jackson2000TheEO,
  title={The effect of dopamine on the rapidly adapting receptors in the dog lung.},
  author={David M. Jackson and William T. Simpson},
  journal={Pulmonary pharmacology & therapeutics},
  year={2000},
  volume={13 1},
  pages={39-42}
}
The effect of an infusion of dopamine (50 microg/kg per min) on both resting and histamine-stimulated discharge of rapidly adapting receptors has been studied in the dog lung. In dogs pretreated with propranolol and phentolamine (1 mg/kg) dopamine inhibited the ability of histamine to stimulate the rapidly adapting receptors. This inhibition was attenuated by sulpiride, a selective D(2)antagonist, (0.5 mg/kg i.v.). Dopamine did not affect the increases in R(L)or the falls in C(dyn)produced by… CONTINUE READING

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