The effect of dobutamine infusion on fractional diaphragm thickening and diaphragm blood flow during fatigue.

  title={The effect of dobutamine infusion on fractional diaphragm thickening and diaphragm blood flow during fatigue.},
  author={N. Smith-Blair and J. Pierce and R. Clancy},
  journal={Heart \& lung : the journal of critical care},
  volume={32 2},
BACKGROUND Diaphragm fatigue (DF) has been implicated in respiratory failure in diseases that increase inspiratory resistance loading (IRL) and may complicate weaning of patients from mechanical ventilation. OBJECTIVE The purpose of this study was to examine the effects of dobutamine administration (10 micro g/kg/min) on DF and to identify the mechanisms by which dobutamine augments diaphragm shortening and diaphragm blood flow (DBF) during fatigue with a rat model. METHODS The study had an… Expand
4 Citations
Dopamine alleviation of diaphragm contractile dysfunction and reduction of deoxyribonucleic acid damage in rats.
Data support the hypothesis that low-dose dopamine during IRL reduced myonuclei DNA damage as measured by the fluorescent dyes and comet analysis and prevent diaphragm fatigue by the administration of dopamine. Expand
Apoptotic-Related Protein Expression in the Diaphragm and the Effect of Dopamine During Inspiratory Resistance Loading
It is suggested that DA decreases diaphragm apoptosis through elevated expression of SOD (CuZn) and proprioceptive event related potential (PERP) in the DA group. Expand
Effects of phosphodiesterase‐III inhibitors on sevoflurane‐induced impairment of rat diaphragmatic function
The aim of the current study was to compare the impairing effect of halothane and sevoflurane on diaphragmatic contractile functions under unfatigued and fatigued conditions and to determine whether phosphodiesterase‐III inhibitors can attenuate sev of lurane‐potentiated reduction of contractility after fatigue. Expand
Resistance Loading Apoptotic-Related Protein Expression in the Diaphragm and the Effect of Dopamine During Inspiratory
  • 2008


RETRACTED ARTICLE: Contractility of fatigued diaphragm is improved by dobutamine
It is concluded that dobutamine improves contractility in fatigued diaphragm by decreasing the pressure of transdiaphragmatic pressure and increasing the strength of the contractility of the phrenic nerves. Expand
Dobutamine increases diaphragmatic contractility in dogs
The results suggest that dobutamine has a stimulating effect on canine diaphragmatic contraction, and this action may be related to the increased inward movement of extracellular calcium. Expand
Effects and mechanism of action of terbutaline on diaphragmatic contractility and fatigue.
Transdiaphragmatic pressure (Pdi) during direct or indirect supramaximal 2-s stimulation applied over a frequency range of 10-100 Hz was measured with balloon catheters during tracheal occlusion at functional residual capacity. Expand
Force reserve of the diaphragm in patients with chronic obstructive pulmonary disease.
  • F. Bellemare, A. Grassino
  • Medicine
  • Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1983
It is concluded that COPD patients can increase their mean Pdi 3-fold before reaching a fatiguing pattern of breathing compared with 8-fold in normal subjects and the remaining force reserve of the diaphragm can be exhausted by even minor modifications in the breathing pattern. Expand
Diaphragmatic pressure waveform can predict electromyographic signs of diaphragmatic fatigue.
It is suggested that this change in Pdi waveform can predict EMG signs of diaphragmatic fatigue and that the F group maintained Pdi less well than the NF group during the latter half of TI. Expand
Role of nitric oxide in vasodilator response induced by salbutamol in rat diaphragmatic microcirculation.
  • H. Chang
  • Medicine
  • The American journal of physiology
  • 1997
The data indicate that in rat diaphragmatic microcirculation salbutamol-induced vasodilation may be partly mediated by beta-adrenoceptors on the endothelium, and suggest that an elevation of cyclic AMP in the endot Helium may cause release of NO. Expand
Pulmonary and leg VO2 during submaximal exercise: implications for muscular efficiency.
The present investigation addressed the issue directly by making simultaneous determinations of pulmonary and leg VO2 over a range of work rates calculated to elicit 20-90% of maximum VO2 on the basis of prior incremental cycle ergometry, suggesting that the net VO2 cost of metabolic "support" processes outside the exercising legs changes little over a relatively broad range of exercise intensities. Expand
Exercise blood flow patterns within and among rat muscles after training.
Data indicate the high-oxidative motor units that are primarily recruited in the muscles during the initial stages of moderate treadmill exercise receive higher blood flows in the trained rats; this presumably contributes to increased resistance to fatigue. Expand
Clinical manifestations of inspiratory muscle fatigue.
The abnormalities of respiratory movements may be reliable clinical signs of inspiratory muscle fatigue, particularly when accompanied by tachypnea and hypercapnia. Expand
β‐Adrenergic Receptor Distribution Among Muscle Fiber Types and Resistance Arterioles of Winte, Red, and Intermediate Skeletal Muscle
It is concluded that β-receptor density of rat hindquarter skeletal muscles is directly proportional to percentage of slow-twitch fibers, while receptor affinity for antagonist is ingher in fast-twitch than in slow-Twin or mixed fiber muscles, and β- receptordensity of resistance arterioles is similar among types of muscles but these vessels are far more numerous in the slow- twitch soleus. Expand