The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes.

Abstract

OBJECTIVE Familial or sporadic male-limited precocious puberty is a distinct and unusual gonadotrophin-independent form of sexual precocity caused by constitutively activating mutations of the luteinizing hormone receptor (LHR). In the present study, we evaluated the effect of known activating mutations at different sites of the LHR gene on the pituitary… (More)

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@article{Latronico2000TheEO, title={The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes.}, author={Ana Claudia Latronico and Theresa S S Lins and V{\^a}nia Nieto Brito and Ivo Jorge Prado Arnhold and Bruna Bueno Mendonça}, journal={Clinical endocrinology}, year={2000}, volume={53 5}, pages={609-13} }