The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression.

  title={The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression.},
  author={Jeong Min Kim and Hei-Cheul Jeung and Sun Young Rha and Eun Jeong Yu and Tae Soo Kim and You Keun Shin and Xianglan Zhang and Kyu H. Park and Seung Woo Park and Hyun Cheol Chung and Garth Powis},
  journal={Molecular cancer therapeutics},
  volume={13 12},
Advanced gastric cancer is one of the most aggressive gastrointestinal malignancies, and ADAM (A disintegrin and metalloproteinase)-9 is a cell-surface membrane glycoprotein with oncogenic properties that is overexpressed in several cancers. Herein, we investigated the biologic mechanism of ADAM9 in the progression, proliferation, and invasion of gastric cancer. First, we detected ADAM's expression, processing, and protease activity in gastric cancer cells. Protease activity was moderately… CONTINUE READING
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Gastrin induces heparin-binding epidermal growth ADAM9 in Gastric Cancer Mol Cancer Ther

  • Y Miyazaki, Y Shinomura, S Tsutsui, S Zushi, Y Higashimoto, S Kanayama
  • December 2014 OF11 Research. on November
  • 2014
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