• Corpus ID: 41359057

The effect of dimethoate and pyrantel on vitamin C concentration in the rat liver.

@article{Spodniewska2006TheEO,
  title={The effect of dimethoate and pyrantel on vitamin C concentration in the rat liver.},
  author={Anna Spodniewska and Arkadiusz Zasadowski},
  journal={Polish journal of veterinary sciences},
  year={2006},
  volume={9 1},
  pages={
          23-9
        }
}
The aim of this study was to determine the content of vitamin C in the liver of rats exposed to dimethoate or pyrantel embonate as well as co-intoxication with both agents. Investigations were carried out in two stages. At each stage, the rats were divided into three experimental groups (I-III) and a control (C) group. In the first stage, rats from group I were administered pyrantel embonate at a two-week interval at a dose of 1/2 LD50, while the animals from group II received dimethoate for 28… 
Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel.
TLDR
It was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.
EFFECT OF ORAL ADMINISTRATION OF DIMETHOATE AND PYRANTEL ON SELECTED PARAMETERS OF PRO- AND ANTIOXIDATIVE PROCESSES IN RATS
TLDR
In the combined intoxication, the profile of changes was similar to that observed in the animals intoxicated with dimethoate only; however, the changes were more pronounced.
Content of Glutathione and Vitamin C in the Liver of Rats Exposed to Dimethoate and Pyrantel Tartrate
TLDR
Pyrantel tartrate was found to increase the concentration of glutathione in the liver, whereas the content of vitamin C oscillated around values reported for the control, which may suggest that not in all cases of mixed intoxications, intensification should be expected in changes of the variables analyzed.
Phenthoate induced-oxidative stress in fresh isolated mice hepatocytes: Alleviation by ascorbic acid
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The findings suggest that cytotoxicity of PTA is mediated by increasing free radical formation and decreasing the antioxidants, which can be very effective in perhaps reducing the extent of injury and in overcoming oxidant damage caused by PTA.

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