The effect of different sulfonamides on phenytoin metabolism in man.

@article{Hansen1979TheEO,
  title={The effect of different sulfonamides on phenytoin metabolism in man.},
  author={Jason Hansen and Jens Peter Konnerup Kampmann and K. Siersbaek-Nielsen and I B Lumholtz and M Arr\oe and Ulrik Abildgaard and L. Skovsted},
  journal={Acta medica Scandinavica. Supplementum},
  year={1979},
  volume={624},
  pages={106-10}
}
The influence on the metabolism of phenytoin of some sulfonamides given in common clinical doses has been studied. In single dose experiments sulfaphenazole increased phenytoin half-life (T/2) by 237% and decreased phenytoin metabolic clearance rate (MCR) by 67%. Sulfadiazine, sulfamethiazole, sulfamethoxazole + trimethoprim and trimethoprim increased… CONTINUE READING