The effect of different regimens of oestrogens on the clotting and fibrinolytic system of the post-menopausal woman.

  title={The effect of different regimens of oestrogens on the clotting and fibrinolytic system of the post-menopausal woman.},
  author={Margaret H. Thom and Mariam Dubiel and Vijay. V. Kakkar and John W. W. Studd},
  journal={Frontiers of hormone research},
The effects of six different regimens of hormone replacement therapy on coagulation, fibrinolysis and platelet aggregation were sudied in 33 symptomatic, post-menopausal women. Studies were performed before and after 3 months of therapy in the six treatment groups, Premarin, Progynova, Harmogen, Serial 28, ethynodiol diacetate and a testosterone and oestradiol implant. No changes in any parameter were detected following administration of Premarin, Progynova or an implant of testosterone and… 

Effects of oral combined hormone replacement therapy on platelet aggregation in postmenopausal women.

Postmenopausal women on oral combined continuous HRT comprising oestradiol and norethisterone had similar whole-blood platelet aggregation rates and maximum platelet Aggregation responses to higher doses of platelet agonists when compared with those on placebo.

Changes in coagulation factors and fibrinolytic components of postmenopausal women receiving continuous hormone replacement therapy.

Except for an increase in factor VII activity in the case of continuous CEE therapy, continuous HRT had no unfavorable effects on either coagulation factors or fibrinolytic components.

Effects of androgens on haemostasis.

Effects of androgens on haemostasis

Effects of subcutaneous oestradiol implants on ovarian activity

The effects of subcutaneous oestradiol implants on ovarian activity were investigated in 14 ovulating premenopausal women and both doses of implant elevated the excretion of oestrone‐3‐glucuronide compared to pretreatment.

Ovarian failure and ageing.

Enhanced hepatic extraction of estrogens used for replacement therapy.

Enhanced delivery of circulating estrogens to the liver compared to that to the brain and uterus provides a further explanation for the enhanced hepatic actions of these preparations when used for oral replacement therapy.

Oestrogen replacement therapy: physiological considerations and new applications.

  • H. Judd
  • Medicine, Biology
    Bailliere's clinical endocrinology and metabolism
  • 1987

Contraception for the older woman

The dilemma faced by older women in finding a method of contraception that is both safe and effective is discussed, and the scope and choice of contraceptive methods available to women over 35 years of age is expanding.