The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations

@article{Ingman2011TheEO,
  title={The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations},
  author={Kimmo Ingman and Tarja Naukkarinen and Mikko Vahteristo and Irja Korpela and Mikko Kuoppam{\"a}ki and Juha Ellm{\'e}n},
  journal={European Journal of Clinical Pharmacology},
  year={2011},
  volume={68},
  pages={281-289}
}
Repeated dosing of levodopa/carbidopa/entacapone (LCE) has shown a favourable pharmacokinetic (PK) profile compared with levodopa/carbidopa (LC), but increases maximum plasma levodopa concentrations (Cmax) during the day. High levodopa concentrations are associated with peak-dose dyskinesias. To determine whether administering LCE 75/18.5/200 and 125/31.5/200 mg (LCE 75 and LCE 125) following a morning dose of LCE 100/25/200 and 150/37.5/200 mg (LCE 100 and LCE 150), respectively, would avoid… CONTINUE READING

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