The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells.

@article{Paluszczak2010TheEO,
  title={The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells.},
  author={Jarosław Paluszczak and Violetta K. Krajka-Kuźniak and Wanda Baer-Dubowska},
  journal={Toxicology letters},
  year={2010},
  volume={192 2},
  pages={119-25}
}
The CpG island methylator phenotype is characterized by DNA hypermethylation in the promoters of several suppressor genes associated with the inactivation of various pathways involved in tumorigenesis. DNA methylation is catalyzed by specific DNA methyltransferases (DNMTs). Dietary phytochemicals particularly catechol-containing polyphenols were shown to inhibit these enzymes and reactivate epigenetically silenced genes. The aim of this study was to evaluate the effect of a wide range of… CONTINUE READING

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