The effect of dietary fat content on phospholipid fatty acid profile is muscle fiber type dependent.

@article{Janovsk2010TheEO,
  title={The effect of dietary fat content on phospholipid fatty acid profile is muscle fiber type dependent.},
  author={Alena Janovsk{\'a} and George Hatzinikolas and Mark Mano and Gary A. Wittert},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 4},
  pages={
          E779-86
        }
}
A high-saturated-fat diet (HFD) induces obesity and insulin resistance (IR). IR has been linked to alterations and increased saturation in the phospholipid composition of skeletal muscles. We aimed to determine whether HFD feeding affects fatty acid (FA) membrane profile in a muscle fiber type-specific manner. We measured phospholipid FAs and expression of FA synthesis genes in oxidative soleus (SOL) and glycolytic extensor digitorum longus (EDL) muscles from rats fed either standard chow… 

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References

SHOWING 1-10 OF 63 REFERENCES

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

Results indicate that increasing dietary Sat induces insulin resistance with concomitant increases in muscle DAG, and diets rich in n-6 PUFA appear to prevent insulin resistance by directing fat into TAG, rather than other lipid metabolites.

Fatty acid composition of skeletal muscle reflects dietary fat composition in humans.

The fatty acid composition of skeletal muscle lipids reflects the fatty acids composition of the diet in healthy men and women, as well as in the skeletal muscle triacylglycerols.

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

It is concluded that the particular fatty acids and the lipid environment in which they are presented in high-fat diets determine insulin sensitivity in rats and impaired insulin action in skeletal muscle relates to triglyceride accumulation, suggesting intracellular glucose–fatty acid cycle involvement.

Effects of changes in dietary fatty acids on isolated skeletal muscle functions in rats.

The effects of manipulating dietary levels of essential polyunsaturated fatty acids on the function of isolated skeletal muscles in male Wistar rats were examined and Manipulation of dietary fatty acids results in significant, but reversible, effects in muscles of rats fed an EFAD diet.

A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle.

A rapid and marked capacity for changes in dietary fatty acid availability to modulate the expression of mRNA-encoding proteins is necessary for fatty acid transport and oxidative metabolism and is evidence of nutrient-gene interactions in human skeletal muscle.

Defining high-fat-diet rat models: metabolic and molecular effects of different fat types.

High-fat (HF)-diet rodent models show an intact transcriptional hepatic insulin effect despite resistance to insulin's metabolic actions, and diets based on LC-SFA and MUFA induced hepatic steatosis with SREBP1c activation.

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle.

It is concluded that the LCACoA content of muscle provides a direct index of intracellular lipid metabolism and its links to insulin action, which, unlike triglyceride content, is not subject to contamination by closely associated adipose tissue.

Relationships between muscle membrane lipids, fiber type, and enzyme activities in sedentary and exercised rats.

Investigation of the relationship between muscle fiber type and membrane fatty acid composition and how voluntary exercise might influence both variables found no significant differences in the fatty acid profile of soleus and extensor digitorum longus.

Dietary fat and insulin action in humans

  • B. Vessby
  • Medicine, Biology
    British Journal of Nutrition
  • 2000
It is suggested that a high proportion of fat in the diet is associated with impaired insulin sensitivity and an increased risk of developing diabetes, independent of obesity and body fat localization, and that this risk may be influenced by the type of fatty acids in the diets.

Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle.

We examined, in muscle of lean and obese Zucker rats, basal, insulin-induced, and contraction-induced fatty acid transporter translocation and fatty acid uptake, esterification, and oxidation. In
...