The effect of dietary calcium on bone metabolism in young and aged female rats using a short-term in vivo model.

@article{Sinha1988TheEO,
  title={The effect of dietary calcium on bone metabolism in young and aged female rats using a short-term in vivo model.},
  author={R. J. Sinha and James Cecil Smith and Joseph H. Soares},
  journal={The Journal of nutrition},
  year={1988},
  volume={118 10},
  pages={1217-22}
}
The use of high dietary calcium supplementation in the treatment of patients with osteoporosis is controversial. The present study examined the mechanisms underlying the effects of calcium supplementation by investigating the influence of dietary calcium on bone dynamics in young and aged rats. A 2 x 2 x 2 factorial design was utilized with 0.2% (low) or 1.0% (high) calcium, 2- or 24-m-old female Long-Evans rats that were implanted subcutaneously with demineralized (DB) and mineralized (MB… CONTINUE READING