The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.

@article{Ge2001TheEO,
  title={The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.},
  author={Rongrong Ge and Shulin Yang and Paula M. Kramer and Lianhui Tao and Michael Ashley Pereira},
  journal={Journal of biochemical and molecular toxicology},
  year={2001},
  volume={15 2},
  pages={100-6}
}
The chlorine disinfection by-products, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA induced DNA hypomethylation in mouse liver. In the present study, we determined the temporal association for DNA hypomethylation and cell proliferation. Female B6C3F1 mice were administered daily doses of 500 mg/kg DCA or TCA by gavage and sacrificed at 24, 36, 48, 72, and 96 hours after the first dose. The proliferating… CONTINUE READING