The effect of dexamethasone in vivo on blood and peritoneal neutrophils (PMN) in rabbits with peritonitis.

@article{Sheng1987TheEO,
  title={The effect of dexamethasone in vivo on blood and peritoneal neutrophils (PMN) in rabbits with peritonitis.},
  author={F C Sheng and Julie Ann Freischlag and B T Backstrom and Darren J. Kelly and Ronald W Busuttil},
  journal={The Journal of surgical research},
  year={1987},
  volume={43 3},
  pages={296-301}
}
Neutrophils play an essential role in the host's defense against infection. Our previous studies have shown that blood and peritoneal neutrophils (PMN) have different basal activities and responses to infection. We also demonstrated that peritonitis produces divergent changes in the cellular function of PMN both in the blood and in the peritoneal fluid. Steroids are well documented to cause immunosuppression both clinically and, more variably, at the cellular level. Understanding the mechanism… CONTINUE READING