The effect of deoxymannojirimycin on the processing of the influenza viral glycoproteins.

@article{Elbein1984TheEO,
  title={The effect of deoxymannojirimycin on the processing of the influenza viral glycoproteins.},
  author={Alan D Elbein and G{\"u}nter Legler and A Tlusty and William P. McDowell and Ralph T. Schwarz},
  journal={Archives of biochemistry and biophysics},
  year={1984},
  volume={235 2},
  pages={579-88}
}
Deoxymannojirimycin (dMM) was tested as an inhibitor of the processing of the oligosaccharide portion of viral and cellular N-linked glycoproteins. The NWS strain of influenza virus was grown in MDCK cells in the presence of various amounts of dMM, and the glycoproteins were labeled by the addition of 2-[3H]mannose to the medium. At levels of 10 micrograms/ml dMM or higher, most of the viral glycopeptides became susceptible to digestion by endoglucosaminidase H, and the liberated… CONTINUE READING

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