Corpus ID: 15186445

The effect of deleterious mutations on neutral molecular variation.

@article{Charlesworth1993TheEO,
  title={The effect of deleterious mutations on neutral molecular variation.},
  author={B. Charlesworth and M. Morgan and D. Charlesworth},
  journal={Genetics},
  year={1993},
  volume={134 4},
  pages={
          1289-303
        }
}
  • B. Charlesworth, M. Morgan, D. Charlesworth
  • Published 1993
  • Biology, Medicine
  • Genetics
  • Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. This is because a new neutral variant can only remain in a large population for a long period of time if it is maintained in gametes that are free of deleterious alleles, and hence are not destined for rapid elimination from the population by selection. Approximate formulas are derived for the reduction below classical neutral values resulting from… CONTINUE READING
    1,622 Citations

    Figures, Tables, and Topics from this paper

    Paper Mentions

    Selection on a modifier of recombination rate due to linked deleterious mutations.
    • S. Pálsson
    • Biology, Medicine
    • The Journal of heredity
    • 2002
    • 11
    The pattern of neutral molecular variation under the background selection model.
    • 366
    • PDF
    The effects of deleterious mutations on linked, neutral variation in small populations.
    • 26
    • Highly Influenced
    • PDF
    Linkage and the limits to natural selection.
    • 341
    • PDF
    The Effects of Deleterious Mutations on Evolution at Linked Sites
    • 229
    • PDF
    Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations.
    • 3
    • PDF
    Reduced Effectiveness of Selection Caused by a Lack of Recombination
    • 102
    Genomic Consequences of Outcrossing and Selfing in Plants
    • 180
    • PDF

    References

    SHOWING 1-10 OF 79 REFERENCES
    Mutation rate and dominance of genes affecting viability in Drosophila melanogaster.
    • 451
    • PDF
    The genomic mutation rate for fitness in Drosophila
    • 100
    The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations.
    • 725
    • Highly Influential
    • PDF
    The hitch-hiking effect of a favourable gene.
    • 2,061
    • PDF
    Mutation-selection balance and the evolutionary advantage of sex and recombination.
    • 378
    • PDF
    Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster
    • 893
    • Highly Influential
    • PDF