Corpus ID: 15186445

The effect of deleterious mutations on neutral molecular variation.

@article{Charlesworth1993TheEO,
  title={The effect of deleterious mutations on neutral molecular variation.},
  author={B. Charlesworth and M. Morgan and D. Charlesworth},
  journal={Genetics},
  year={1993},
  volume={134 4},
  pages={
          1289-303
        }
}

B. Charlesworth, M. Morgan, D. Charlesworth

Published 1993

Biology, Medicine

Genetics

Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. This is because a new neutral variant can only remain in a large population for a long period of time if it is maintained in gametes that are free of deleterious alleles, and hence are not destined for rapid elimination from the population by selection. Approximate formulas are derived for the reduction below classical neutral values resulting from… CONTINUE READING

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