The effect of dehydroemetine on isolated guinea‐pig atria

@article{Durotoye1972TheEO,
  title={The effect of dehydroemetine on isolated guinea‐pig atria},
  author={A O Durotoye and L. A. Salako},
  journal={British Journal of Pharmacology},
  year={1972},
  volume={44}
}
1 The mechanism of the inhibitory effect of dehydroemetine on the heart was investigated using spontaneously contracting isolated guinea‐pig atria. 2 In normal Locke solution, dehydroemetine caused a reduction in the rate and amplitude of contraction of the atria. The effect was antagonized by adrenaline and augmented by acetylcholine. 3 Increasing the potassium concentration of the bathing medium increased the inhibitory effect of dehydroemetine on the atria, while decreasing the potassium… Expand
7 Citations
The actions of dehydroemetine on isolated guinea‐pig atria. Influence of ouabain and calcium
  • L. Salako
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1972
TLDR
It was concluded that the effects of dehydroemetine on rate and contractility are, to a large extent, independent of one another. Expand
Effect of dehydroemetine on myocardial circulation and contractility in vivo.
TLDR
It is concluded that the only primary effect of the drug on the heart is a depression of the myocardium and that any observed reduction in coronary blood flow is secondary to this. Expand
Some characteristics of the adrenergic neurone blocking action of dehydroemetine
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Emetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitro.
  • S. J. Pan, A. Combs
  • Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 1995
TLDR
The pharmacological effects of emetine perfusion included decreased contractility which occurred concurrently with P-R interval prolongation, QRS duration prolongation and degeneration of the QRS waveform, and the most significant toxicological effect was the large amounts of LDH which appeared in the coronary effluent. Expand
Metabolic effects of 9-day emetine treatment in rabbits.
TLDR
Results appeared to reflect the inanition induced by chronic emetine treatment, rather than a primary action of the drug, and no impairment of [ 3 H]leucine incorporation was observed in either organ and any differences observed between the three groups were reversible after recovery. Expand
Chapter 1 Ipecac Alkaloids and β-Carboline Congeners
Publisher Summary This chapter discusses the chemistry and synthesis of all of the 7 ipecac alkaloids and 24 Alangium alkaloids reported so far. By 1971 synthetic routes to the main groups of theExpand
Mechanism of emetine cardiotoxicity.

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