The effect of dehydroemetine on isolated guinea‐pig atria

  title={The effect of dehydroemetine on isolated guinea‐pig atria},
  author={A O Durotoye and L. A. Salako},
  journal={British Journal of Pharmacology},
1 The mechanism of the inhibitory effect of dehydroemetine on the heart was investigated using spontaneously contracting isolated guinea‐pig atria. 2 In normal Locke solution, dehydroemetine caused a reduction in the rate and amplitude of contraction of the atria. The effect was antagonized by adrenaline and augmented by acetylcholine. 3 Increasing the potassium concentration of the bathing medium increased the inhibitory effect of dehydroemetine on the atria, while decreasing the potassium… 
7 Citations
The actions of dehydroemetine on isolated guinea‐pig atria. Influence of ouabain and calcium
  • L. Salako
  • Chemistry, Medicine
    British journal of pharmacology
  • 1972
It was concluded that the effects of dehydroemetine on rate and contractility are, to a large extent, independent of one another.
Effect of dehydroemetine on myocardial circulation and contractility in vivo.
It is concluded that the only primary effect of the drug on the heart is a depression of the myocardium and that any observed reduction in coronary blood flow is secondary to this.
Some characteristics of the adrenergic neurone blocking action of dehydroemetine
The uptake of dehydroemetine by adrenergic neurones was studied indirectly by testing the ability of various procedures to prevent or reverse adrenergic neurone blockade in the periarterially
Emetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitro.
  • S. J. Pan, A. Combs
  • Medicine
    Toxicology in vitro : an international journal published in association with BIBRA
  • 1995
The pharmacological effects of emetine perfusion included decreased contractility which occurred concurrently with P-R interval prolongation, QRS duration prolongation and degeneration of the QRS waveform, and the most significant toxicological effect was the large amounts of LDH which appeared in the coronary effluent.
Metabolic effects of 9-day emetine treatment in rabbits.
Results appeared to reflect the inanition induced by chronic emetine treatment, rather than a primary action of the drug, and no impairment of [ 3 H]leucine incorporation was observed in either organ and any differences observed between the three groups were reversible after recovery.
Chapter 1 Ipecac Alkaloids and β-Carboline Congeners
Publisher Summary This chapter discusses the chemistry and synthesis of all of the 7 ipecac alkaloids and 24 Alangium alkaloids reported so far. By 1971 synthetic routes to the main groups of the
Mechanism of emetine cardiotoxicity.


The influence of potassium concentration on the action of quinidine and of some antimalarial substances on cardiac muscle.
  • A. Armitage
  • Chemistry, Medicine
    British journal of pharmacology and chemotherapy
  • 1957
During exposure to any of the antimalarial compounds tested, the normal inhibitory action of acetylcholine was converted to a stimulant action and there were slight differences in behaviour between proguanil and quinidine on the one hand, and chloroquine, mepacrine and pyrimethamine on the other.
Effect of dehydroemetine on isolated preparations of rabbit and guinea-pig heart and atria.
Dhydroemetine in low concentrations decreases the rate and force of spontaneous contraction of the isolated rabbit and guinea-pig heart and atria suggesting that the drug prolongs the effective refractory period of the myocardium.
The stimulatory action of acetylcholine on isolated rabbit atria.
It is suggested that ACh restarted atria arrested by quinidine by an action on the sodium "carrying system" (excitatory mechanism) and this was not the result of an increase in MRP.
The mode of action of quinidine on isolated rabbit atria interpreted from intracellular potential records.
It has been concluded that quinidine prolongs the effective refractory period by slowing the phase of depolarization, without any change necessarily occurring in the half-time for repolarized, which determines the absolute refraction period.
The mode of action of quinidine on isolated rabbit atria interpreted from intracellular potential records.
An attempt has been made to show why quinidine, which has long been known not to lengthen the duration of the cardiac action potential, measured with external electrodes, and also not to lengthen,
Observations on the hypotensive response to dehydrometine.
Abstract Dehydroemetine reduced blood pressure and produced adrenergic neurone block in the anaesthetised cat but the time courses of the two effects were different. Dehydroemetine also increased the
The membrane resting and action potentials of the cat auricle
The experiments in this paper were carried out to measure the normal auricular potentials in the cat to provide a basis for comparison for later experiments on the effects of vagus stimulation and acetylcholine on the auricle.
Interactions of K, Na, and vagal stimulation in the S-A node of the rabbit.