The effect of cytostatic drug treatment on intestine-specific transcription factors Cdx2, GATA-4 and HNF-1α in mice

@article{Koning2005TheEO,
  title={The effect of cytostatic drug treatment on intestine-specific transcription factors Cdx2, GATA-4 and HNF-1α in mice},
  author={Barbara A. E. de Koning and Dicky J. Lindenbergh-Kortleve and Rob Pieters and Edmond H. H. M. Rings and Hans A. B{\"u}ller and Ingrid B. Renes and Alexandra W. C. Einerhand},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={57},
  pages={801-810}
}
Chemotherapy-induced intestinal damage is a very important dose-limiting side effect for which there is no definitive prophylaxis or treatment. This is in part due to the lack of understanding of its pathophysiology and impact on intestinal differentiation. The objective of this study was to investigate the gene expression of the small intestinal transcription factors HNF-1α, Cdx2, GATA-4 in an experimental model of methotrexate (MTX)-induced intestinal damage, and to correlate these… CONTINUE READING

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