The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes.

@article{Wicks1992TheEO,
  title={The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes.},
  author={Ian P Wicks and T. Leizer and Steve Wawryk and Jennifer Novotny and James Hamilton and G F Vitti and Andrew W. Boyd},
  journal={Autoimmunity},
  year={1992},
  volume={12 1},
  pages={13-9}
}
We report the expression on synovial cells of cell surface molecules known to be involved in T cell activation by antigen presenting cells. Normal human synovial fibroblasts and a human synovial cell line transformed with the SV40 large T antigen were used for in vitro stimulation studies with recombinant cytokines. We demonstrate an increase in MHC-A, B, C expression in normal synovial cells in response to recombinant interferon gamma (r gamma IFN), tumour necrosis factor alpha and beta (rTNF… CONTINUE READING
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