The effect of cyproheptadine on the chromosomes of human lymphocytes in vitro.

@article{Hite1977TheEO,
  title={The effect of cyproheptadine on the chromosomes of human lymphocytes in vitro.},
  author={M. Lee Hite and J Algon and Harold M. Peck},
  journal={Arzneimittel-Forschung},
  year={1977},
  volume={27 6},
  pages={
          1203-6
        }
}
The effect of 4-[5-dibenzo(alpha,alpha)-cyclohepten-5-ylidene]-1-methylpiperidine (cyproheptadine, Periactinol) on the chromosomes of human lymphocytes in vitro was investigated. Cell cultures that had been established for 48 h from lymphocytes obtained from the peripheral blood of four volunteers were exposed for an additional 24 h to drug concentrations of 2.54 X 10(-5), 5.09 X 10(-5), 1.02 X 10(-4), or 2.03 X 10(-4) Mol/l. No variations or aberrations were seen in the chromosomes of human… CONTINUE READING

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