The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: implication to their mode of action.

@article{Unger2001TheEO,
  title={The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: implication to their mode of action.},
  author={Tamar Unger and Ziv Oren and Yechiel Shai},
  journal={Biochemistry},
  year={2001},
  volume={40 21},
  pages={6388-97}
}
The amphipathic alpha-helical structure is a common motif found in membrane binding polypeptides including cell lytic peptides, antimicrobial peptides, hormones, and signal sequences. Numerous studies have been undertaken to understand the driving forces for partitioning of amphipathic alpha-helical peptides into membranes, many of them based on the… CONTINUE READING