The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes.

@article{Mihic2014TheEO,
  title={The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes.},
  author={Anton Mihic and Jiao Li and Yasuo Miyagi and Mark Gagliardi and Shu-hong Li and Jean W. Zu and Richard D. Weisel and Gordon M. Keller and R. K.-Y. Li},
  journal={Biomaterials},
  year={2014},
  volume={35 9},
  pages={2798-808}
}
The goal of cardiac tissue engineering is to restore function to the damaged myocardium with regenerative constructs. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can produce viable, contractile, three-dimensional grafts that function in vivo. We sought to enhance the viability and functional maturation of cardiac tissue constructs by cyclical stretch. hESC-CMs seeded onto gelatin-based scaffolds underwent cyclical stretching. Histological analysis demonstrated a greater… CONTINUE READING
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