The effect of cryopreservation on the genome of gametes and embryos: principles of cryobiology and critical appraisal of the evidence.

@article{Kopeika2015TheEO,
  title={The effect of cryopreservation on the genome of gametes and embryos: principles of cryobiology and critical appraisal of the evidence.},
  author={Julia Y Kopeika and Alan Russell Thornhill and Yakoub Khalaf},
  journal={Human reproduction update},
  year={2015},
  volume={21 2},
  pages={209-27}
}
BACKGROUND Cryopreservation has been extensively used in assisted reproductive technology, agriculture and conservation programmes for endangered species. The literature reports largely positive results regarding the survival of frozen-thawed cells and clinical outcomes. Nonetheless, it is unclear whether or not cryopreservation of sperm, oocytes and embryos causes any disruption in their genetic integrity. Drawing on the available published evidence, this review paper describes in detail the… CONTINUE READING
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