The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection

@article{Zhang2000TheEO,
  title={The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection},
  author={Er-ping Zhang and Felix H Schulte and Silvia Bulfone-Paus and Friedrich Hoffmann},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2000},
  volume={238},
  pages={525-530}
}
Background: The immunomodulatory T-helper type 1 (Th1) cytokine interferon-γ (IFN-γ) was measured in serum and cornea to ascertain its general contribution to corneal graft rejection and to establish a rational basis for the decision for or against systemic therapy. Methods: Eight groups of differently treated BALB/c (H-2d) mice received a C3H (H-2 k) corneal graft. There was one saline-treated control group and two groups that received intramuscular cyclosporin A (CsA) for 14 or 40. Three… CONTINUE READING
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