The effect of copper excess on iron metabolism in sheep.

@article{Theil1978TheEO,
  title={The effect of copper excess on iron metabolism in sheep.},
  author={Elizabeth C. Theil and K T Calvert},
  journal={The Biochemical journal},
  year={1978},
  volume={170 1},
  pages={137-43}
}
Sheep were treated with large amounts of copper (20 mg of CuSO4,5H2O/kg body wt. per day) for 9 weeks to examine the effect of copper excess on iron metabolism. In addition to confirming that massive haemolysis and accumulation of copper occurs in the liver, kidney and plasma after 7 weeks of exposure to excess copper, it was observed that excess copper produced an increased plasma iron concentration and transferrin saturation within 1 week. Further, iron preferentially accumulated in the… CONTINUE READING