The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function

@inproceedings{Jin2011TheEO,
  title={The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function},
  author={Wei Jin and Shijie Qi and Hongyu Luo},
  booktitle={BMC Immunology},
  year={2011}
}
Eph kinases are the largest family of cell surface receptor tyrosine kinases. The ligands of Ephs, ephrins (EFNs), are also cell surface molecules. Ephs interact with EFNs transmitting signals in both directions, i.e., from Ephs to EFNs and from EFNs to Ephs. EFNB1 is known to be able to co-stimulate T cells in vitro and to modulate thymocyte development in a model of foetal thymus organ culture. To further understand the role of EFNB1 in T cell immunity, we generated T-cell-specific EFNB1 gene… CONTINUE READING