The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells.


OBJECTIVE To investigate the combined effects of cisplatin and the histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) or sirtinol on HeLa cells and assess the mechanism underlying HDAC inhibitor-cisplatin synergy. METHODS The antineoplastic actions of cisplatin, SAHA and sirtinol, alone and in combination, were evaluated using… (More)
DOI: 10.3802/jgo.2010.21.4.262

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