The effect of combined ischaemia and acidosis on lactate uptake and gluconeogenesis in the perfused rat liver.

@article{Iles1981TheEO,
  title={The effect of combined ischaemia and acidosis on lactate uptake and gluconeogenesis in the perfused rat liver.},
  author={Richard A Iles and Robert Donald Cohen and ParametersR. Baron},
  journal={Clinical science},
  year={1981},
  volume={60 5},
  pages={537-42}
}
1. Perfused rat livers were subjected to an acid perfusate and varying degrees of ischaemia in an attempt to simulate the conditions of strenuous exercise or shock. 2. Lactate uptake and glucose output from the liver decreased during moderate ischaemia alone and more so when, in addition, the perfusate was made acidic. 3. Hepatic ATP and ADP content… CONTINUE READING