The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice.

@article{Chawira1987TheEO,
  title={The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice.},
  author={A N Chawira and David Charles Warhurst and Brian L. Robinson and Wallace Peters},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={1987},
  volume={81 4},
  pages={554-8}
}
Artemisinin is a novel antimalarial drug isolated in China from the wormwood plant Artemisia annua L. Studies with rodent malaria were carried out to detect antagonism and synergism with a variety of antimalarial drugs. Isobolograms of drug interaction were plotted at the ED90 level. With a normally susceptible strain of Plasmodium berghei, marked potentiative synergism was found with mefloquine, tetracycline and spiramycin. There was some synergism also with primaquine. Combinations of… CONTINUE READING
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