The effect of cobra venom factor on alternative pathway hemolytic activity in mice.

@article{Joiner1980TheEO,
  title={The effect of cobra venom factor on alternative pathway hemolytic activity in mice.},
  author={Keith A. Joiner and A. Hawiger and Jeffrey Gelfand},
  journal={Immunological communications},
  year={1980},
  volume={9 3},
  pages={277-81}
}
The in vivo effect of cobra venom factor (CVF) on murine alternative complement pathway hemolytic activity was measured with a recently developed microassay. Four different dosage schedules of CVF were compared. Hemolytic titers were lowered to less than 5% of the baseline value by 6 hours after the first dose of CVF (62.5 - 200 U/kg), and remained low for 3-5 days, depending upon total dose, route and schedule of CVF administration. Titers at days 6-9 after initial CVF injection increased… CONTINUE READING