The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial.

  title={The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial.},
  author={Michaela K. Farber and Rodney Schultz and L Lugo and X. Liu and C. C. Huang and Lawrence C Tsen},
  journal={Obstetric Anesthesia Digest},
BACKGROUND Oxytocin administration to prevent uterine atony following cesarean delivery is associated with adverse effects including hypotension, tachycardia, and nausea. Calcium chloride increases mean arterial pressure, systemic vascular resistance, and uterine smooth muscle contractility. This study evaluated whether the co-administration of calcium chloride with oxytocin following cesarean delivery could alter maternal hemodynamics. Secondary outcomes included uterine tone and blood loss… 
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The Effect of Extracellular Calcium on Oxytocin-Induced Contractility in Naive and Oxytocin-Pretreated Human Myometrium In Vitro

In oxytoc in-naive myometrium, normocalcemia provides superior oxytocin-induced contractility compared with hypocalcemic and hypercalcemic conditions, and these observations warrant further investigations in laboratory and clinical settings.

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Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.

The three most effective drugs for prevention of Postpartum haemorrhage were ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxyocin combination - the drug currently recommended by the WHO.

Uterotonics and tocolytics for anesthesiologists

Anesthesiologists involved in obstetric anesthesia should be able to determine the appropriate uterotonic for cesarean section and know the indication of tocolytics in perinatal period.



Oxytocin Requirements at Elective Cesarean Delivery: A Dose-Finding Study

The bolus dose of oxytocin used at elective cesarean deliveries in nonlaboring women can be significantly reduced while maintaining effective uterine contraction, but may require modification of the techniques to remove the placenta.

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Routine intramyometrial 15-methyl prostaglandin F2 alpha, 125 micrograms, does not offer any obvious advantage over intravenous oxytocin, 20 U, in reducing operative blood loss at elective lower-segment cesarean section.

Minimum effective bolus dose of oxytocin during elective Caesarean delivery.

The routine use of 5 units Oxytocin during elective CD can no longer be recommended, as adequate UT can occur with lower doses of oxytocin (0.5-3 units).

Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients.

An initial bolus of oxytocin 5 u produced prominent haemodynamic changes, whereas a second bolus produced smaller changes, which could be due to desensitization of endothelial Oxytocin receptors.

Haemodynamic Effects of Oxytocin (Syntocinon®) and Methyl Ergometrine (Methergin®) on the Systemic and Pulmonary Circulations of Pregnant Anaesthetized Women

The haemodynamic effects of oxytocin (Syntocinon®) and methyl ergometrin (Methergin®) were studied in 9 healthy females in the first trimester of pregnancy and the use of Oxytocic drugs in patients with compromised circulation is discussed.

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This study demonstrates a potency ratio of 81.2 (95% CI 73.0-89.7) for equivalence between phenylephrine and ephedrine in prevention of hypotension after spinal anaesthesia for Caesarean section.

Pulmonary edema possibly developing secondary to the intravenous administration of oxytocin.

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Impact of dose‐finding studies on administration of oxytocin during caesarean section in the UK

There is a trend towards the use of lower doses of oxytocin in caesarean section, but there are still wide variations in detail, and it is suggested that there is a need for a national protocol to standardise oxytocIn administration.