The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial.
@article{Farber2015TheEO, title={The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial.}, author={Michaela K. Farber and Rodney Schultz and L Lugo and X. Liu and C. C. Huang and Lawrence C Tsen}, journal={Obstetric Anesthesia Digest}, year={2015} }
BACKGROUND
Oxytocin administration to prevent uterine atony following cesarean delivery is associated with adverse effects including hypotension, tachycardia, and nausea. Calcium chloride increases mean arterial pressure, systemic vascular resistance, and uterine smooth muscle contractility. This study evaluated whether the co-administration of calcium chloride with oxytocin following cesarean delivery could alter maternal hemodynamics. Secondary outcomes included uterine tone and blood loss…
10 Citations
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In oxytoc in-naive myometrium, normocalcemia provides superior oxytocin-induced contractility compared with hypocalcemic and hypercalcemic conditions, and these observations warrant further investigations in laboratory and clinical settings.
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The serum calcium levels and uterine atonicity and PPH in women admitted in 1st and 2nd stage of labor in tertiary care hospital like Sri Chamarajendra hospital Hassan institute of medical sciences, Karnataka, India were correlated.
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
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- 2020
There were no clear differences between groups for maternal hypertension requiring intervention, and rates of bradycardia were lower in the ephedrine group than in the crystalloid group, and there were no serious adverse effects with any of the interventions investigated.
The Inter-Rater Reliability and Agreement of a 0 to 10 Uterine Tone Score in Cesarean Delivery.
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Association between ionised calcium and severity of postpartum haemorrhage: a retrospective cohort study.
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- 2020
Uterotonic agents for preventing postpartum haemorrhage: a network meta‐analysis
- MedicineThe Cochrane database of systematic reviews
- 2018
The network meta‐analysis suggested that all agents were effective for preventing PPH ≥ 500 mL when compared with placebo or no treatment, and the three highest ranked uterotonic agents for prevention of PPH were ergometrine plus oxytocin combination, misoprostol plus oxyocin combination and carbetocin.
Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.
- MedicineThe Cochrane database of systematic reviews
- 2018
The three most effective drugs for prevention of Postpartum haemorrhage were ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxyocin combination - the drug currently recommended by the WHO.
Uterotonics and tocolytics for anesthesiologists
- MedicineCurrent opinion in anaesthesiology
- 2016
Anesthesiologists involved in obstetric anesthesia should be able to determine the appropriate uterotonic for cesarean section and know the indication of tocolytics in perinatal period.
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