The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis

@inproceedings{Sharp2013TheEO,
  title={The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis},
  author={Sally Isabel Sharp and Ying Hu and Jon F. Weymer and Mie A Rizig and Andrew McQuillin and Stephen P. Hunt and Hugh M.D. Gurling},
  booktitle={Psychiatric genetics},
  year={2013}
}
OBJECTIVES Clathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs), into clathrin-coated vesicles (CCVs). The antipsychotic chlorpromazine inhibits CCV assembly of adaptor protein AP2 whereas clozapine increases serotonin2A receptor internalization. We hypothesized that… CONTINUE READING