The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.

@article{Muoz1990TheEO,
  title={The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.},
  author={Juan Jos{\'e} Fern{\'a}ndez Mu{\~n}oz and Rafael Enr{\'i}quez de Salamanca and C Diaz-Obreg{\'o}n and F L Timoneda},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={29 6},
  pages={763-5}
}
Steady state metabolite/parent drug plasma ratios were measured in 15 epileptic patients on carbamazepine (CBZ) monotherapy and in seven patients treated with CBZ and clobazam (CLB). CBZ plasma concentrations did not differ between the two groups but patients also treated with CLB exhibited higher concentrations of CBZ-10,11-epoxide (CBZ-E) and trans-10,11… CONTINUE READING