The effect of claustrum lesions on human consciousness and recovery of function

@article{Chau2015TheEO,
  title={The effect of claustrum lesions on human consciousness and recovery of function},
  author={Aileen Chau and Andres M. Salazar and Frank Krueger and Irene Cristofori and Jordan Henry Grafman},
  journal={Consciousness and Cognition},
  year={2015},
  volume={36},
  pages={256-264}
}
Crick and Koch proposed that the claustrum plays a crucial role in consciousness. Their proposal was based on the structure and connectivity of the claustrum that suggested it had a role in coordinating a set of diverse brain functions. Given the few human studies investigating this claim, we decided to study the effects of claustrum lesions on consciousness in 171 combat veterans with penetrating traumatic brain injuries. Additionally, we studied the effects of claustrum lesions and loss of… 
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References

SHOWING 1-10 OF 34 REFERENCES
The claustrum’s proposed role in consciousness is supported by the effect and target localization of Salvia divinorum
TLDR
It is suggested that the claustrum does indeed serve as a conductor for certain aspects of higher-order integration of brain activity, while integration of auditory and visual signals relies more on coordination by other areas including parietal cortex and the pulvinar.
The claustrum : structural, functional, and clinical neuroscience
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being
Consciousness and the brainstem
TLDR
A theoretical framework and a set of hypotheses aimed at accounting for consciousness in neurobiological terms are summarized and the functional neuroanatomy of nuclei in the brainstem reticular formation is discussed because they constitute the basic set of somato-sensing structures necessary for core consciousness and its core self to emerge.
Chapter 13 – Hypotheses Relating to the Function of the Claustrum
This chapter presents a comprehensive hypothesis relating to the function of the claustrum derived from the original Crick-Koch hypothesis. We suggest that it is concerned with operations on cortical
Functional compensation of the claustrum: lessons from low-grade glioma surgery
TLDR
A series of 42 right-handed patients operated for acerebral glioma involving the claustrum, with func-tional recovery in all cases but three, despite a claustralremoval, is reported.
The DTI connectivity of the human claustrum
TLDR
It is found that the claustrum has the highest connectivity in the brain by regional volume and is ideally located within the human central nervous system (CNS) connectome to serve as the putative “gate keeper” of neural information for consciousness awareness.
Neurochemically defined cell types in the claustrum of the cat
TLDR
The identification of multiple neurochemical cell classes, their distribution and the extent of their dendritic arborizations relative to functional compartments suggest a substrate for information processing in the claustrum that may allow integration of information across functional subdivisions.
Does brief loss of consciousness affect cognitive functioning after mild head injury?
  • G. Iverson, M. Lovell, S. Smith
  • Psychology, Medicine
    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
  • 2000
TLDR
Three groups of 65 patients were given a brief battery of neuropsychological tests within one week of sustaining a mild head injury and there were no significant differences among the groups on any of the measures of attention, learning, memory, language, or executive functioning.
The neuropathology of the vegetative state after an acute brain insult.
TLDR
A detailed neuropathological study of the brains of 49 patients who remained vegetative until death, 1 month to 8 years after an acute brain insult, finds profound damage to the subcortical white matter or to the major relay nuclei of the thalamus renders any structurally intact cortex unable to function.
DURATION OF IMPAIRED CONSCIOUSNESS IN RELATION TO SIDE OF LESION AFTER SEVERE HEAD INJURY
TLDR
Use of verbal methods to assess level of consciousness may be responsible for the observation that lesions of the language dominant hemisphere produce greater disturbance of consciousness than similar insults to the right hemisphere.
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