The effect of citrate and other compounds on PMN incubated in vitro: further studies on the site and mechanism of action of citrate.

@article{Pfister1984TheEO,
  title={The effect of citrate and other compounds on PMN incubated in vitro: further studies on the site and mechanism of action of citrate.},
  author={Roswell R. Pfister and Jeffrey L. Haddox and R. W. Dodson and V P Germann},
  journal={Cornea},
  year={1984},
  volume={3 4},
  pages={
          240-9
        }
}
Polymorphonuclear leukocytes (PMN) are important in corneal disease because of their role as effector cells in inflammation and ulceration. The favorable effect of citrate on corneal ulceration appears to result from inhibition of the PMN. Citrate does not enter the cells but chelates Ca2+ in the extracellular fluid and may promote a loss of some intracellular Ca2+. Isocitrate is the only tricarboxylic acid cycle intermediate that inhibits PMN, also by Ca2+ chelation. When isobutylcyanoacrylate… CONTINUE READING