The effect of cirrhosis on the disposition and elimination of clindamycin

Abstract

This study assessed the effect of alcoholic cirrhosis in man and of experimental liver injury in rats on the disposition and elimination of clindamycin. In 7 cirrhotics a statistically significant, although modest, prolongation of clindamycin half-life (T1/2β) was observed as compared to values in 7 agematched normal controls (mean ±SD: 4.46±0.93, hr vs 3… (More)
DOI: 10.1007/BF01070725

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