The effect of cinnarizine and cocculus indicus on simulator sickness

  title={The effect of cinnarizine and cocculus indicus on simulator sickness},
  author={Marco Lucertini and Nadia Mirante and Maria Casagrande and Pierandrea Trivelloni and Vittoria Lugli},
  journal={Physiology \& Behavior},
Oculo-vestibular recoupling using galvanic vestibular stimulation to mitigate simulator sickness.
When virtual head signals produced by GVS are synchronized to the speed and direction of a moving visual field, manifestations of induced SS in a cockpit flight simulator are significantly reduced.
No Effects of Anti-Motion Sickness Drugs on Vestibular Evoked Myogenic Potentials Outcome Parameters
  • R. Vanspauwen, Aurelie P. Weerts, F. Wuyts
  • Medicine, Biology
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2011
The absence of clinically significant effects can be explained by the predominant presence of the target receptors for the applied drugs in the medial vestibular nucleus, which receives the lowest grade of saccular projections.
Neuronal Mechanisms and the Treatment of Motion Sickness
An overview of the physiological basis, clinical picture and treatment options for motion sickness is provided and scopolamine and antihistamines are the most effective drugs.
Motion Sickness Prediction in Aeromedical Evacuation of Patients with Ebola.
A test flight was conducted to quantify this risk during the transfer of an Ebola patient from West Africa to Italy and decided to use anti-MS drugs only in selected cases, including those with positive past history of MS, gastrointestinal disorders, or residual carsickness.
Influence du mal de mer sur le travail de chercheurs embarqués à bord de navires océanographiques français
Purpose of the study. The objective of this work is to study the importance and the effects of seasickness on the workstation aboard, among oceanographers. Method. The study was conducted by an
Motion Sickness: Current Knowledge and Recent Advance
This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS, and indicates that the sensory conflict hypothesis is the most widely accepted theory for MS.
All compounds 1a-c did not cause any mortality or changes in general behavior of the test animals at oral treatment of 5000 mg/kg BW indicating no conspicuous toxicity at the highest dose administered.
Voltammetric Behavior and Determination of Cinnarizine in Pharmaceutical Formulations and Serum
Abstract The electrochemical reduction of cinnarizine was investigated by cyclic and linear sweep adsorptive voltammetry at glassy carbon electrode in Britton-Robinson buffers over the pH range


The combined effect of cinnarizine and domperidone on vestibular susceptibility
It appears that the new preparation Touristil approaches the profile of the ideal drug against motion sickness more closely than any other medication.
Central effects of cinnarizine: restricted use in aircrew.
Cinnarizine is not free of central activity over the usual therapeutic dose range of 15 to 30 mg, and is contraindicated for motion sickness in aircrew involved in the control of aircraft.
Effect of cinnarizine in the prevention of seasickness.
Cinnarizine 50 mg was found to be effective in the prevention of seasickness in rough seas and no notable side effects were found for any drug group.
Cinnarizine in the prophylaxis of seasickness: Laboratory vestibular evaluation and sea study
It is concluded that 50 mg cinnarizine is an effective drug for the prevention of seasickness and the reduction in vestibular sensitivity observed even after administration of 25mg cinnarezine may explain the potency of cinnARizine in the Prevention of Seasickness.
A comparison of the efficacy of cinnarizine with scopolamine in the treatment of seasickness.
Scopolamine was shown to be more effective than cinnarizine in protecting against the symptoms of seasickness and in mild motion, cinnARizine was better tolerated than scopolamine in having less marked side effects.
Cinnarizine—a labyrinthine sedative
  • G. Towse
  • Biology
    The Journal of Laryngology & Otology
  • 1980
The role of cinnarizine in the management of motion sickness and Vertigo is reviewed.
Effect of betahistine dihydrochloride compared with cinnarizine on induced vestibular nystagmus.
A significant difference was seen in the duration of nystagmus during initial acceleration, and in average eye speed following the sudden stop after treatment with cinnarizine.
Disorientation and postural ataxia following flight simulation.
Some evidence is provided for the validity of the disorientation subscale of the SSQ and it is suggested that the postural instability observed after simulator exposure may, in fact, result from dis orientation.
Promethazine, scopolamine and cinnarizine: comparative time course of psychological performance effects
Promethazine and cinnarizine significantly impaired psychomotor performance, information processing and feelings of alertness, and memory task performance; the overall performance effects were most evident 1–4 h post-drug.
Limitations of postural equilibrium tests for examining simulator sickness.