The effect of cimetidine on tolbutamide kinetics.

  title={The effect of cimetidine on tolbutamide kinetics.},
  author={N G Dey and Christopher M Castleden and Jeffrey Ward and J. Frederick Cornhill and Alan McBurney},
  journal={British journal of clinical pharmacology},
  volume={16 4},
Although possible on theoretical grounds, no interaction between cimetidine and tolbutamide could be demonstrated in ten healthy volunteers. The plasma tolbutamide concentrations over 12 h following 0.5 g orally were essentially the same before and after 1 and 7 days cimetidine (400 mg twice daily). 

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