The effect of chronic thienorphine administration on long-term potentiation and synaptic structure in rat hippocampus.

@article{Yong2013TheEO,
  title={The effect of chronic thienorphine administration on long-term potentiation and synaptic structure in rat hippocampus.},
  author={Z. Z. Yong and Lingdi Yan and Zhaoqi Dong and Xiao Wang and Rui-bin Su and Zehui Gong},
  journal={Synapse},
  year={2013},
  volume={67 11},
  pages={779-85}
}
Thienorphine is a new nonselective partial agonist of opioid receptors, which is currently under a Phase II clinical trial in China as a new treatment for opioid dependence. In this study, we compared the effect of thienorphine with morphine on long-term potentiation (LTP) in the lateral perforant path (LPP)-granule cell synapse of the rat dentate gyrus (DG). Furthermore, the effect of thienorphine on the synaptic structure of the CA1 hippocampal region and the expression of synaptophysin was… CONTINUE READING