The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivo.

@article{Ichikawa1992TheEO,
  title={The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivo.},
  author={Junji Ichikawa and Herbert Y Meltzer},
  journal={Brain research},
  year={1992},
  volume={574 1-2},
  pages={98-104}
}
The effect of chronic administration of antipsychotic drugs (21 days in drinking water followed by 3 days drug washout) on the D-amphetamine (1.0 mg/kg, s.c.)-induced increase in dopamine (DA) release in the striatum and the nucleus accumbens of awake, freely-moving rats was investigated with microdialysis. Chronic administration of haloperidol, a typical antipsychotic, (0.5 mg/kg/day), decreased basal extracellular DA release in the striatum and the nucleus accumbens but did not affect D… CONTINUE READING

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